Formulation and Evaluation of Tetanus Leaf (Leea aequata L.) Ethanol Extract on Tablet Preparation using Wet Granulation Method
Main Article Content
Abstract
Degenerative diseases are currently widely suffered, especially in Indonesian society, as many as 30% of the population is detected with degenerative diseases. One alternative treatment that is widely consumed by Indonesian society is herbal or traditional medicine, one of the plants that is widely consumed by society, especially in Indonesia, namely Tetanus Leea Aequata L leaves. These leaves are often found, especially in the Karo area. The purpose of this study was to use ethanol extract of tetanus Leea Aequata leaves as tablets using the wet granulation method. The content contained in the leaves, such as Flavonoids, can be used as an alternative medicine to treat degenerative diseases by using a comparison of muchilago amyli used as a binder, namely f1 20%, f2 10% and F3 5% based on this study, a formula was obtained that can be used to make tablets, namely formula 1 20% muchilago amyli
Article Details
References
Nasri, N., Silalahi, J., Kaban, V. E. & Satria, D. A Review on The Benefits of Probiotics as Fermented Food against Several Diseases. J. Funct. Food Nutraceutical 41–52 (2023).
Satria, D. et al. Synergistic Antibacterial Effect of Ethyl Acetate Fraction of Vernonia amygdalina Delile Leaves with Tetracycline against Clinical Isolate Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Adv. Pharmacol. Pharm. Sci. 2023, 1–11 (2023).
Kaban, V. E., Thomas, N. A. & Sholihah, I. PENGANTAR ILMU FARMASI.
Nasri, N., Kaban, V. E., Gurning, K., Syahputra, H. D. & Satria, D. Aktivitas Antibakteri Ekstrak Etanol Daun Pepaya (Carica papaya Linn.) Terhadap Bakteri Pseudomonas aeruginosa. INSOLOGI J. Sains Dan Teknol. 1, 252–259 (2022).
Cook, T. M., Protheroe, R. T. & Handel, J. M. Tetanus: a review of the literature. Br. J. Anaesth. 87, 477–487 (2001).
Fitri, R., Syahputra, H. D., Nasri, N., Kaban, V. E. & Rani, Z. Formulation of a biocellulose mask containing the essence of Aloe vera (L.) Burm. f combination with vitamin E as anti-aging. Sci. Pharm. Sci. 36–42 (2022).
Ginting, N., Suwarso, E., Rumapea, D. V. & Nerdy, N. Relaxation activity of tetanus (Leea aequata L.) leaf ethanolic extract on Guinea pig isolated trachea. Asian J Pharm. Clin Res 11, 24–27 (2018).
Elisya, Y., Kardono, L. B. & Simanjuntak, P. Tablet formulation of the ethyl acetate soluble extract of soursop (Annona muricata L.) leaves. Asian J. Appl. Sci. 2, (2014).
Mudrić, J. et al. Tablet and capsule formulations incorporating high doses of a dry optimized herbal extract: The case of Satureja kitaibelii. J. Drug Deliv. Sci. Technol. 66, 102776 (2021).
Saryanti, D. Formulasi dan Uji Stabilitas Fisik Sediaan Tablet Ekstrak Buah Pare (Momordica charantia L.) secara Granulasi Basah. Smart Med. J. 2, 25–31 (2019).