https://nusantarascientificjournal.com/index.php/pcjn/issue/feed 2026-01-19T06:41:53+00:00 Mesy Puspita Sari, S.Farm. nusantarascientific.journal@gmail.com Open Journal Systems <p><em data-start="0" data-end="57" data-is-only-node="">Pharmaceutical and Clinical Journal of Nusantara (PCJN)</em> (E-ISSN: 2985-4040) is a triannual scientific journal published by <strong data-start="125" data-end="157">Nusantara Scientific Medical</strong>, offering a specialized platform for high-quality research in key areas of pharmaceutical and clinical sciences. With its focused scope—ranging from pharmaceutical biology and technology to clinical pharmacy and microbiology—PCJN serves as a bridge between regional scientific developments and broader global discourse, supporting the advancement of evidence-based practices through a rigorous peer-review process and collaborative academic environment.</p> https://nusantarascientificjournal.com/index.php/pcjn/article/view/137 2026-01-15T03:56:58+00:00 Irma Suryani Nasution irmanasution@gmail.com Anggie Patrisia Siregar anggiepatrisiasiregar@gmail.com Astriani Natalia Br Ginting astrianinataliabrginting@unprimdn.ac.id Vera Estefania Kaban veraestefaniakaban@unprimdn.ac.id Roy Indrianto Bangar Siagian royindriantobangars@unprimdn.ac.id

<p><em>Hyperuricemia is a metabolic disorder caused by elevated serum uric acid levels that may progress to gout and other complications. Although synthetic drugs such as allopurinol are effective, their long-term use may cause adverse effects, thus alternative therapies derived from natural products are needed. This study aimed to evaluate the antihyperuricemic activity of the ethanol extract of kedondong pagar leaves (Lannea coromandelica (Houtt.) Merr.) in male white rats (Rattus norvegicus). An in vivo experimental study was conducted using potassium oxonate–induced hyperuricemic rats. The animals were divided into five groups: negative control (0.5% CMC), positive control (allopurinol 10 mg/kgBW), and three treatment groups receiving the ethanol extract at doses of 100, 200, and 300 mg/kgBW. Serum uric acid levels were measured before induction, after induction, and hourly up to six hours following treatment. Phytochemical screening revealed the presence of flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides in the extract. The results demonstrated that the ethanol extract of Lannea coromandelica leaves significantly reduced serum uric acid levels in a dose-dependent manner, with the 300 mg/kgBW dose showing the greatest effect and approaching the efficacy of allopurinol. In conclusion, the ethanol extract of kedondong pagar leaves has potential as a natural antihyperuricemic agent.</em></p>

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